Title: Extramammary myofibroblastoma in the head and neck region
Authors: Hox, Valerie
Vander Poorten, Vincent
Delaere, Pierre
Hermans, Robert
Debiec-Rychter, Maria
Sciot, Raphael # ×
Issue Date: Sep-2009
Publisher: J. Wiley
Series Title: Head & Neck vol:31 issue:9 pages:1240-1244
Abstract: Mammary myofibroblastoma is a benign mesenchymal tumor of the breast. Extramammary location is very rare and usually occurs along the embryonic milk-line. METHODS AND RESULTS: In this article, we present a case of a woman with an infra-auricular swelling. A diagnosis could not be made on CT scans, so the mass was surgically removed. Histological examination showed spindle cells in clusters, with CD34, desmin, and actin expression. The diagnosis of extramammary myofibroblastoma was made. CONCLUSION: We describe this case because of the unusual location of this rare tumor. Furthermore, we want to highlight the possible relationship between (extra)mammary myofibroblastoma and spindle cell lipoma (SCL). SCL has a predilection site in the posterior neck. Both tumors show the same clinical behavior, a close histological resemblance, and their cells are both immunoreactive for CD34 and CD10. The loss of RB/13q14 and FKHR/13q14 loci, which is typically found in SCL cells, was also shown in this case. (c) 2009 Wiley Periodicals, Inc. Head Neck, 2009.
ISSN: 1043-3074
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Research Group Experimental Oto-rhino-laryngology
Translational Cell & Tissue Research
Department of Experimental Medicine (-)
Clinical Genetics Section (-)
Laboratory of Experimental Transplantation
Laboratory for Genetics of Malignant Disorders
Head and Neck Oncology (+)
× corresponding author
# (joint) last author

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