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Title: Concise microwave-assisted synthesis of 2-aminoimidazole marine sponge alkaloids of the isonaamines series
Authors: Ermolat'ev, D. S ×
Alifanov, V. L
Rybakov, V. B
Babaev, E. V
Van der Eycken, Erik #
Issue Date: Jul-2008
Publisher: Thieme Chemistry
Series Title: Synthesis issue:13 pages:2083-2088
Abstract: A short and efficient route to 1,4-substituted 2-aminoimidazole alkaloids starting from the easily accessible 2-alkylaminopyrimidines and a.-bromo aldehydes is reported. The formation of the intermediate imidazo[1,2-a]pyrimidinium salts and subsequent cleavage were facilitated by microwave irradiation. Marine sponge alkaloids preclathridines A, C and isonaamines A, C, D were obtained in high yields using the optimized one-pot two-step procedure.
ISSN: 0039-7881
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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