Title: Synthesis of furo[2,3-b]pyrazine nucleoside analogues with 1,2,3-triazole linkage
Authors: Ermolat'ev, Denis S ×
Mehta Pravinchandra, Vaibhav
Van der Eycken, Erik #
Issue Date: Dec-2007
Publisher: Wiley-v c h verlag gmbh
Series Title: QSAR & Combinatorial Science vol:26 issue:11-12 pages:1266-1273
Abstract: Sonogashira coupling reaction with the readily available 1-(4-methoxybenzyl)-3,5-dichloropyrazin-2(1H)-ones was followed by mild silver-catalyzed cyclization to provide the corresponding 2-chlorofuro[2,3-b]pyrazines in excellent yields. A second Sonogashira cross-coupling reaction resulted in the formation of 2-ethynylfuro[2,3-b]pyrazines, which were coupled with D-ribose and 2-deoxy-D-ribose using a microwave-assisted Cu(I)-catalyzed Huisgen [2+3] dipolar cycloaddition reaction, to generate a small library of new nucleoside analogues.
ISSN: 1611-020X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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