Title: Motor function following multilevel botulinum toxin type A treatment in children with cerebral palsy
Authors: Desloovere, Kaat ×
Molenaers, Guy
De Cat, Jos
Pauwels, Petra
Van Campenhout, Anja
Ortibus, Els
Fabry, Guy
De Cock, Paul #
Issue Date: Jan-2007
Publisher: Heinemann William Medical Books
Series Title: Developmental Medicine and Child Neurology vol:49 issue:1 pages:56-61
Abstract: This study evaluated the effects of multilevel botulinum toxin type A (BTX-A) treatments on the gait pattern of children with spastic cerebral palsy (Gross Motor Function Classification System Levels I-III). In this nested case-control design, 30 children (mean age 6y 11mo [SD 1y 5mo]; 21 males, nine females; 19 with hemiplegia, 11 with diplegia) were treated according to best practice guidelines in paediatric orthopaedics, including BTX-A injections. A matched control group of 30 children (mean age 7y 8mo [SD 1y 10mo]; 13 males, 17 females; 19 with hemiplegia, 11 with diplegia) were treated identically, but without BTX-A. Motor development status at 5 to 10 years of age was assessed by means of three-dimensional gait analysis at a mean time of 1 year 10 months (SD 10mo) after the last BTX-A treatment. The control group showed a significantly more pronounced pathological gait pattern than the BTX-A group. Major differences were found for pelvic anterior tilt, maximum hip and knee extension, and internal hip rotation. These results provide evidence for a prolonged effect of BTX-A and suggest that BTX-A injections, in combination with common conservative treatment options, result in a gait pattern that is less defined by secondary problems (e.g. bony deformities) at 5 to 10 years of age, minimizing the need for complex surgery at a later age and enhancing quality of life.
ISSN: 0012-1622
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Brain & Metabolism Section (-)
Research Group for Neuromotor Rehabilitation
Orthopaedics Section (-)
Youth Health (-)
× corresponding author
# (joint) last author

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