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Title: Small intestinal brush border enzymes in cystic fibrosis
Authors: Van Biervliet, S ×
Eggermont, Ephrem
Carchon, Hubert
Veereman, G
De Boeck, Christiane #
Issue Date: Jul-1999
Publisher: Acta Medica Belgica
Series Title: Acta Gastro-Enterologica Belgica vol:62 issue:3 pages:267-271
Abstract: The study concerns the maltase, saccharase, lactase and alkaline phosphatase activity in small intestinal biopsy specimens from 61 consecutively admitted, untreated, Caucasian cystic fibrosis patients. A group of 319 age matched controls admitted during the same time period for undefined gastrointestinal or nutritional disorders acted as the controls. In order to eliminate morphological damage as a confounding factor, the enzyme activities were studied in small intestinal biopsy specimens having both normal stereomicroscopic and histological features. It was shown that neither maltase nor saccharase activity was different in the two groups, in contrast to lactase and alkaline phophatase activity, that was significantly lower in cystic fibrosis patients. The differences could not be explained by the nutritional status as judged by the body mass index. Lactase activity is known to be easily affected by numerous enteropathies. As the information on alkaline phosphatase activity is limited, the low activity is discussed in more detail. Taking into account the literature data, the low alkaline phosphatase activity is tentatively attributed either to enhanced release from the brush border or to the faulty handling of alkaline phophatase protein in the post-golgi compartments secondary to the accumulation of incorrectly glycosylated CFTR in the same cell structures.
ISSN: 0001-5644
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine - miscellaneous
Brain & Metabolism Section (-)
Laboratory of Pediatric Immunology
× corresponding author
# (joint) last author

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