Title: Alpha-glycosidase activity in seminal plasma: predictive value for outcome in intrauterine insemination and in vitro fertilization
Authors: Spiessens, C ×
D'Hooghe, Thomas
Wouters, E
Meuleman, Christel
Vanderschueren, Dirk #
Issue Date: Apr-1998
Series Title: Fertility and Sterility vol:69 issue:4 pages:735-9
Abstract: OBJECTIVE: To test the hypothesis that alpha-glycosidase activity in seminal plasma can predict the outcome of both IUI and IVF. DESIGN: A retrospective cohort study. SETTING: Tertiary fertility center in a university hospital. PATIENT(S): Eighty-three subfertile couples who underwent IUI and 125 subfertile couples who underwent IVF. INTERVENTION: None. MAIN OUTCOME MEASURE(S): Determination of the alpha-glycosidase activity in seminal plasma before an IUI or IVF attempt, correlation of alpha-glycosidase activity and other semen parameters, and prediction of pregnancy using alpha-glycosidase activity in seminal plasma. RESULT(S): Alpha-glycosidase activity correlated with sperm count. In the IUI group, alpha-glycosidase activity of >23.9 mU/mL predicted pregnancy with a sensitivity of 100% and a specificity of 55.2%. In the IVF group, the outcome could not be predicted with use of any of the semen parameters. CONCLUSION(S): Alpha-glycosidase activity measured in mU/mL probably can be used as a predictor for IVF and pregnancy in an IUI program but has no predictive value with regard to pregnancy rate in an IVF program.
ISSN: 0015-0282
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Reproductive Medicine Section (-)
Department of Development and Regeneration - miscellaneous (+)
× corresponding author
# (joint) last author

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