Title: Diversity oriented microwave-assisted synthesis of (-)-Steganacin aza-analogues
Authors: Mont, Nuria ×
Mehta Pravinchandra, Vaibhav
Appukkuttan, Prasad
Beryozkina, Tetyana
Toppet, Suzzane
Van Hecke, Kristof
Van Meervelt, Luc
Voet, Arnout
De Maeyer, Marc
Van der Eycken, Erik #
Issue Date: Oct-2008
Publisher: American Chemical Society
Series Title: Journal of Organic Chemistry vol:73 issue:19 pages:7509-7516
Abstract: A novel microwave-assisted, highly efficient protocol for the synthesis of hitherto unknown aza-analogues of (-)-Steganacin, a naturally occurring bisbenzocyclooctadiene lignan lactone with potent antileukemic and tubulin polymerization inhibitory activity, has been developed. Focused microwave irradiation is demonstrated to be highly beneficial in promoting the three crucial steps of the sequence to effect the final ring closure: the Suzuki-Miyaura reaction, Cu-mediated A 3-coupling, as well as the intramolecular Huisgen 1,3-dipolar cycloaddition.
ISSN: 0022-3263
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
Biochemistry, Molecular and Structural Biology Section
Molecular Design and Synthesis
× corresponding author
# (joint) last author

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