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Title: Clostridium spores as anti-tumour agents
Authors: Van Mellaert, Lieve
Barbé, Sofie
AnnĂ©, Jozef # ×
Issue Date: Apr-2006
Publisher: Elsevier science london
Series Title: Trends in Microbiology vol:14 issue:4 pages:190-196
Abstract: The successful treatment of cancer remains a huge challenge. Consequently, efforts are being made to develop alternative methods of tumour therapy. One of these is the use of live Clostridium species, based on the observation that obligatory anaerobic bacteria specifically colonize the hypoxic and necrotic regions that are present in solid tumours but normally absent in other parts of the body. Although past results have fuelled scepticism about its clinical use, recent promising findings emphasize the potential of Clostridium-directed tumour therapy. These recent developments are reviewed and the reintroduction of this tumour-targeting protein delivery system into clinical settings is discussed.
URI: 
ISSN: 0966-842X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Bacteriology (Rega Institute)
× corresponding author
# (joint) last author

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