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Title: Differential effects of IL-11 on rat blastocysts and decidua during the peri-implantation period
Authors: Caluwaerts, Silvia ×
Pijnenborg, Robert
Luyten, C
Keith, J C
Van Assche, Frans Andre #
Issue Date: Apr-2002
Series Title: American journal of reproductive immunology (New York, N.Y. : 1989) vol:47 issue:4 pages:231-41
Abstract: PROBLEM: To study effects of interleukin-11 (IL-11) on blastocyst development and decidualization. METHOD OF STUDY: Rats, injected with buffer (C) or IL-11 [1 mg/kg/day = high dose (HD), 60 microg/kg/week = low dose (LD)-1, 30 microg/kg twice a week = low dose (LD)-2] were made pregnant or pseudopregnant to obtain blastocysts or deciduomata. RESULTS: As compared with C, more LD-2 blastocysts hatched in culture, while hatching and attachment of HD blastocysts was decreased. Blastocysts from untreated rats in IL-11 supplemented medium (4 ng/mL) demonstrated increased hatching and attachment. The weight of the decidualized uterus in HD and LD-2 pseudopregnant rats was reduced as compared with C and LD- 1. On deciduomata sections from IL-11 treated rats, the area inside the uterine muscle layer was reduced, and mitotic over pycnotic indices were increased in the anti-mesometrial area and decreased in the mesometrial area. CONCLUSIONS: Low doses of IL-11 improve hatching and attachment of blastocysts, but both high and low doses impair decidualization.
URI: 
ISSN: 1046-7408
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pathophysiology of Pregnancy Section (-)
Section Woman - Miscellaneous (-)
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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