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Title: Cervical cotinine and macrophage-Langerhans cell density in the normal human uterine cervix
Authors: Poppe, Willy ×
Peeters, R
Drijkoningen, Maria
Ide, P S
Daenens, Paul
Lauweryns, J M
Van Assche, Frans Andre #
Issue Date: Jan-1996
Series Title: Gynecologic and obstetric investigation vol:41 issue:4 pages:253-9
Abstract: Cotinine levels in blood and cervical fluid of smokers and non-smokers were analysed using capillary-column gas chromatography. These levels were not related to numerical cell densities of intraepithelial S100-protein- and LN2-positive Langerhans cells or to MAC-387-positive macrophages in the stroma of the transformation zone of normal uterine cervices. A decrease in the number of Langerhans cells was noted in smokers, especially in those using oral contraceptives (OCs). Macrophages were more numerous in the endocervical stroma of smokers, suggesting a local response to smoke constituents. These findings may indicate a synergistic suppression of local cervical immunity by smoking and OCs.
ISSN: 0378-7346
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Woman - Miscellaneous (-)
Basic Research in Gynaecology Section (-)
Interdepartmental Platform Hospital Care
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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