Title: Placental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency
Authors: Verhaeghe, Johan ×
Bougoussa, M
Van Herck, E
de Zegher, Francis
Hennen, G
Igout, A #
Issue Date: Nov-2000
Series Title: Clinical endocrinology vol:53 issue:5 pages:645-7
Abstract: The respective contributions of pituitary and placental GH to circulating IGF-I in pregnant women have not been well established. We measured the serum concentrations of placental growth hormone (PGH) and IGF-I in a woman with pit-1 deficiency before, during and after pregnancy, resulting in the birth of a healthy child (not pit-1 deficient). Both PGH and IGF-I concentrations were below the assay detection limit before and after pregnancy. During pregnancy, PGH and IGF-I levels increased steadily; the concentrations of PGH and IGF-I in late pregnancy were comparable with levels previously measured in normal pregnancies. PGH and IGF-I concentrations were strongly correlated throughout pregnancy (r = 0.90; P = 0.002). PGH was undetectable in cord serum, whilst the IGF-I concentration was within the normal range. The findings of this case study corroborate the notion that PGH is the prime regulator of maternal serum IGF-I during pregnancy.
ISSN: 0300-0664
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pathophysiology of Pregnancy Section (-)
Section Newborn (-)
× corresponding author
# (joint) last author

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