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Title: Lymphocytes and dendritic cells in the normal uterine cervix. An immunohistochemical study
Authors: Poppe, Willy ×
Drijkoningen, Maria
Ide, P S
Lauweryns, J M
Van Assche, Frans Andre #
Issue Date: Dec-1998
Series Title: European Journal of Obstetrics & Gynecology and Reproductive Biology vol:81 issue:2 pages:277-82
Abstract: OBJECTIVE: Assessment of the appearance, distribution and numerical density of immune cell populations in the normal human uterine cervix. STUDY DESIGN: SETTING: University Hospital Gasthuisberg. SUBJECTS: 29 healthy women undergoing total hysterectomy for non-cervical benign uterine disease. ANALYSIS: Immunohistochemistry and morphometrical analysis on histological sections containing ectocervix, transformation zone and endocervix, using antibodies against the following antigens: HLA-DR, CD4, CD22, CD1a and CD8. STATISTICAL ANALYSIS: Wilcoxon rank sum test. RESULTS: Lymphocytes in the epithelial and stromal compartments are predominantly T-lymphocytes. Intraepithelial T-lymphocyte and Langerhans' cell densities and their distribution are not influenced by the menstrual cycle and are the same in both ectocervix and transformation zone. CONCLUSION: The wide variation of T lymphocyte subpopulations and Langerhans' cell densities in the normal epithelium of the uterine cervix is stressed. We are the first to present a large and well-defined control series, which is indispensable to study the effect of smoking and other factors on the cervical immune system.
ISSN: 0301-2115
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Woman - Miscellaneous (-)
Basic Research in Gynaecology Section (-)
Interdepartmental Platform Hospital Care
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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