Title: Recent developments in the use of vitamin D analogues
Authors: Verstuyf, Annemieke ×
Segaert, Siegfried
Verlinden, Lieve
Casteels, Kristina
Bouillon, Roger
Mathieu, Chantal #
Issue Date: Jul-1998
Series Title: Current opinion in nephrology and hypertension vol:7 issue:4 pages:397-403
Abstract: The activated form of vitamin D3, 1 alpha,25(OH)2D3, not only plays a central role in bone and calcium metabolism, but also has potent antiproliferative and prodifferentiating effects. Moreover, the combined presence of 25(OH)D3-1 alpha-hydroxylase, as well as the vitamin D receptor in several tissues introduced the idea of a paracrine role for 1 alpha,25(OH)2D3. By introducing chemical modifications into the flexible molecule 1 alpha,25(OH)2D3, a whole generation of vitamin D analogues was created. Due to a clear dissociation of the antiproliferative and prodifferentiating effects from calcaemic effects, these analogues can be used not only for the treatment of bone disorders but also for non-classical applications. In the present review, a summary is given on the use of the 1 alpha,25(OH)2D3 analogues for the treatment of psoriasis, cancer and immune disorders together with new insights in the mechanism of action of these analogues.
ISSN: 1062-4821
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Medical Clerkships Centers
Laboratory of Dermatology
Laboratory of Pediatric Immunology
Laboratory of Dermatoimmunology (+)
× corresponding author
# (joint) last author

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