FunNet meeting edition:2 location:Gosau, Austria date:12-15 September 2007
The Saccharomyces cerevisiae membrane receptor protein Izh2/Pho36 can trigger apoptosis via the cAMP-PKA pathway by binding the plant pathogenesis-related (PR) protein family 5 representative osmotin (see next box). A structural homolog of Pho36 in mammalian cells is the adiponectin receptor AdipoR. It’s been described that osmotin can functionally activate this receptor. Another structural homolog of Pho36 is Candida albicans Ipf19546. We are investigating whether C.a. Ipf19546 can act as a binding receptor to adiponectin, and hence can activate downstream apoptosis pathway(s).