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Title: Investigation of an osmotin/adiponectin-like receptor in the human pathogen Candida albicans
Authors: Radke, Klaus
Tournu, Hélène
Van Dijck, Patrick #
Issue Date: Sep-2007
Conference: FunNet meeting edition:2 location:Gosau, Austria date:12-15 September 2007
Abstract: The Saccharomyces cerevisiae membrane receptor protein Izh2/Pho36 can trigger apoptosis via the cAMP-PKA pathway by binding the plant pathogenesis-related (PR) protein family 5 representative osmotin (see next box). A structural homolog of Pho36 in mammalian cells is the adiponectin receptor AdipoR. It’s been described that osmotin can functionally activate this receptor. Another structural homolog of Pho36 is Candida albicans Ipf19546. We are investigating whether C.a. Ipf19546 can act as a binding receptor to adiponectin, and hence can activate downstream apoptosis pathway(s).
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Molecular Microbiology and Biotechnology Section - miscellaneous
Laboratory for Molecular Cell Biology (-)
# (joint) last author

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