Title: Body mass index and HER-2 overexpression in breast cancer patients over 50 years of age
Authors: Van Mieghem, Tim ×
Leunen, K
Pochet, N
De Moor, Bart
De Smet, Frank
Amant, Frédéric
Berteloot, P
Timmerman, Dirk
Vanden Bempt, Isabelle
Drijkoningen, Maria
Wildiers, Hans
Paridaens, Robert
Smeets, Ann
Hendrickx, Wouter
Van Limbergen, Erik
Christiaens, Marie-Rose
Vergote, Ignace
Neven, Patrick #
Issue Date: Nov-2007
Series Title: Breast Cancer Research and Treatment vol:106 issue:1 pages:127-133
Abstract: PURPOSE: In breast cancer, in vitro as well as in vivo experiments have shown an inverse relationship between HER-2 and steroid hormone receptors. It is unknown whether circulating estrogens affect HER-2 expression. We hypothesize that the postmenopausal body mass index (BMI) as a surrogate marker for bio-available estrogens, is inversely associated with HER-2 over-expression. PATIENTS AND METHODS: A total of 535 women over age 50 or with known postmenopausal status, with a unilateral, not previously treated, operable breast cancer were evaluated the evening prior to surgery for body weight, height, abdominal and hip circumference over a 3 years period. Waist-to-hip ratio (WHR) and BMI were calculated. HER-2, estrogen receptor and progesterone receptor staining was done by immunohistochemistry. All tumours with DAKO 2+ staining were submitted for HER-2 detection by FISH analysis. HER-2 was defined as positive if DAKO 3+ or FISH positive. We assessed the frequency of HER-2 positivity in each of 6 quantiles for all parameters of body composition and tested for a trend in HER-2 expression across the 6 quantiles. Furthermore, we investigated whether BMI contributed, together with other known predictors for HER-2, in a standard multivariate logistic regression model that predicts HER-2 over-expression. RESULTS: There is a decrease in HER-2 over-expression per increasing quantile of BMI. In a multivariate model-including both steroid receptors-BMI remains an independent predictor for HER-2 over-expression. CONCLUSION: In women over age 50 or with known postmenopausal status with an operable breast cancer, there is an inverse association between BMI and HER-2 over-expression.
ISSN: 0167-6806
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Environment and Health - miscellaneous
Basic Research in Gynaecology Section (-)
ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
Multidisciplinary Breast Clinic Section (-)
Surgical Oncology
Laboratory of Experimental Radiotherapy
Laboratory of Experimental Oncology
Section Woman - Miscellaneous (-)
Gynaecological Oncology
× corresponding author
# (joint) last author

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