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Title: A prospective randomized study: day 2 versus day 5 embryo transfer
Authors: Van der Auwera, Ingrid ×
Debrock, Sophie
Spiessens, Carl
Afschrift, Hilde
Bakelants, Els
Meuleman, Christel
Meeuwis, Luc
D'Hooghe, Thomas #
Issue Date: Jun-2002
Publisher: Published for the European Society of Human Reproduction and Embryology by IRL Press
Series Title: Human Reproduction vol:17 issue:6 pages:1507-12
Abstract: BACKGROUND: This randomized controlled study was performed in an unselected IVF/ICSI population to test the hypothesis that blastocyst transfers result in higher clinical pregnancy rates (CPR) per oocyte retrieval when compared with day 2 transfers. METHODS: Blind randomization for transfer on day 2 (group 1) or day 5/6 (group 2) was performed before stimulation. Oocytes and embryos were cultured in sequential media in 5.5% CO(2), 5% O(2), 89.5% N(2) and 90% humidity. A maximum of two embryos was transferred. RESULTS: The two groups were similar for age, IVF indication, number of treatment cycles, rate of ICSI/IVF, number of fertilized oocytes and number of embryos transferred. The CPR/oocyte retrieval was comparable in group 1 (32%) and in group 2 (44%), while the CPR/embryo transfer was significantly higher (P < 0.01) in group 2 (60%) than in group 1 (35%). Similarly, the implantation rate per embryo transferred was significantly higher (P < 0.03) in group 2 (46%) than in group 1 (29%). The cryo-augmented delivery rate/oocyte retrieval was comparable in group 2 (36.3%) and in group 1 (28.6%). CONCLUSION: This randomized study in an unselected population showed a significantly higher CPR/embryo transfer and a tendency toward a higher CPR/oocyte retrieval in patients receiving blastocysts when compared with day 2 transfers.
URI: 
ISSN: 0268-1161
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Reproductive Medicine Section (-)
Assisted Reproductive Technology Laboratory (-)
Department of Development and Regeneration - miscellaneous (+)
× corresponding author
# (joint) last author

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