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Title: Long-term consequences for offspring of diabetes during pregnancy
Authors: Van Assche, Frans Andre ×
Holemans, Kathleen
Aerts, Leona #
Issue Date: Jan-2001
Series Title: British medical bulletin vol:60 pages:173-82
Abstract: There is evidence that the diabetic intra-uterine environment has consequences for later life. Maternal diabetes mainly results in asymmetric macrosomia. This macrosomia is associated with an increased insulin secretion and overstimulation of the insulin producing B-cells during fetal life. In later life, a reduced insulin secretion is found. Intra-uterine growth restriction is present in severe maternal diabetes associated with vasculopathy. Intra-uterine growth restriction is associated with low insulin secretion and reduced development of the insulin receptors. In later life, these alterations can induce insulin resistance. The long-term consequences of an abnormal intra-uterine environment are of primary importance world-wide. Concentrated efforts are needed to explore how these long-term effects can be prevented.
ISSN: 0007-1420
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Woman - Miscellaneous (-)
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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