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Title: PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats
Authors: Verbaeys, Isabelle ×
Leon-Tamariz, F
Pottel, Hans
Decuypere, Eddy
Swennen, Quirine
Cokelaere, Marnix #
Issue Date: Oct-2008
Publisher: Nature publishing group
Series Title: British Journal of Pharmacology vol:155 issue:3 pages:417-423
Abstract: Background and purpose: The physiological involvement of endogenous cholecystokinin (CCK) in the termination of feeding has been challenged by evidence of aversive effects of exogenous CCK8. We previously prolonged the anorectic effect of CCK by conjugation to polyethylene glycol (PEGylation) to produce PEG-CCK9. In this study, we investigated the ability of different doses of PEG-CCK9 to induce conditioned taste aversion (CTA) and satiety and identified the receptors involved in CTA induction.
ISSN: 0007-1188
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine, Campus Kulak Kortrijk
Anatomy, Kulak (-)
Division of Livestock-Nutrition-Quality (-)
× corresponding author
# (joint) last author

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