British Journal of Pharmacology
Author:
Keywords:
cholecystokinin, pegylated cholecystokinin, conditioned taste aversion, satiety, malaise, 2-nap, devazepide, food-intake, octapeptide, antagonist, prolongs, lithium, drugs, Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, PEGylated cholecystokinin, 2-NAP, FOOD-INTAKE, OCTAPEPTIDE, ANTAGONIST, PROLONGS, LITHIUM, DRUGS, Animals, Anorexia, Aspartic Acid, Avoidance Learning, Cholecystokinin, Devazepide, Dose-Response Relationship, Drug, Injections, Intraperitoneal, Male, Naphthalenesulfonates, Peptide Fragments, Polyethylene Glycols, Rats, Rats, Wistar, Receptor, Cholecystokinin A, Saccharin, Satiety Response, Taste, 1115 Pharmacology and Pharmaceutical Sciences, 3214 Pharmacology and pharmaceutical sciences
Abstract:
Background and purpose: The physiological involvement of endogenous cholecystokinin (CCK) in the termination of feeding has been challenged by evidence of aversive effects of exogenous CCK8. We previously prolonged the anorectic effect of CCK by conjugation to polyethylene glycol (PEGylation) to produce PEG-CCK9. In this study, we investigated the ability of different doses of PEG-CCK9 to induce conditioned taste aversion (CTA) and satiety and identified the receptors involved in CTA induction.