Distributed by the Almqvist & Wiksell Periodical Co.
Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery vol:43 issue:1 pages:36-40
The active cellular component in Dupuytren disease (DD) is alpha-smooth muscle actin (alpha-SMA)containing myofibroblasts. The underlying regulatory processes in activation of myofibroblasts resemble the pathophysiology of certain types of cancer. Accumulation of beta-catenin has been shown in many fibroproliferative processes, including DD and recent findings attributed a possible role to the Zicl transcription factor. To assess Zicl expression in DD and investigate its relation with the accumulation of beta-catenin, neighbouring tissue samples in 20 patients with DD were stained immunohistochemically with monoclonal antibodies for beta-catenin, alpha-SMA, and Zicl. Histological appearance was staged according to Luck. Cellrich areas with accumulatioin of beta-catenin in myofibroblasts that stained for alfa-SMA and showed apparent Zicl coexpression were obvious. This coexpression seemed independent of proliferative or involutional histological staging. We found only Zicl expression in residual stages. A different pattern of expression of protein in the residual stage may support earlier suggestions of a heterogeneity with the existence of different cell (sub-)populations in nodules and cords. On the other hand coexpression on Zicl and beta-catenin may indicate a relation between Zicl and the Wnt-pathway. Further studies are needed to elucidate cellular origin, potential heterogeneity and activity of the myofibroblasts in DD, and to define the axact role of Zicl in fibroproliferative processes, wound healing, and cancer. The fibroblast in DD is an interesting model for future experiments.