Title: Pathogenesis of congenital cystic adenomatoid malformation of the lung
Authors: Moerman, Philippe ×
Fryns, Jean-Pierre
Vandenberghe, K
Devlieger, Hugo
Lauweryns, J M #
Issue Date: Oct-1992
Series Title: Histopathology vol:21 issue:4 pages:315-21
Abstract: Congenital cystic adenomatoid malformation is a rare developmental abnormality of the lung. In most earlier reported cases, the anatomy of the bronchial tree was poorly documented. We describe four cases studied following autopsy. Post-mortem bronchography or serial microscopical examination showed segmental bronchial absence or atresia in each of them. Our observations provide further evidence pointing to bronchial atresia as being the primary defect leading to the development of congenital cystic adenomatoid malformation. The morphology of the lesion, i.e. the type of malformation, is determined by the extent of dysplastic lung growth beyond the atretic segment. The aetiology of the bronchial atresia is probably heterogeneous and may either represent a primary malformation, or be the result of vascular disruption.
ISSN: 0309-0167
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical Genetics Section (-)
Translational Cell & Tissue Research
Section Newborn (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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