Title: Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast
Authors: Aerts, A.
Zabrocki, Piotr
Govaert, Gilmer
Mathys, Janick
Carmona-Gutierrez, D.
Madeo, F.
Winderickx, Joris
Cammue, Bruno ×
Thevissen, Karin #
Issue Date: Jan-2009
Series Title: FEBS Letters vol:583 issue:1 pages:113-117
Abstract: We previously isolated a Saccharomyces cerevisiae mutant (HsTnII), which displays 40% reduced chronological lifespan as compared to the wild type (WT). In this study, we found HsTnII cultures to be characterized by fragmented and dysfunctional mitochondria, and by increased initiation of apoptosis during chronological aging as compared to WT. Expression of genes encoding subunits of mitochondrial electron transport chain and ATP synthase is significantly downregulated in HsTnII, and as a consequence, HsTnII is not able to respire ethanol. All these data confirm the importance of functional mitochondria and respiration in determining yeast chronological lifespan and apoptosis.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Physiology of Plants and Micro-organisms Section - miscellaneous
Molecular Genetics Section (-)
Centre of Microbial and Plant Genetics
Laboratory of Molecular Biology of Leukemia (VIB-KU Leuven Center for Cancer Biology)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science