Title: A convenient microwave-assisted desulfitative dimethylamination of the 2(1H)-pyrazinone scaffold using N,N-dimethylformamide
Authors: Sharma, Anuj ×
Mehta Pravinchandra, Vaibhav
Van der Eycken, Erik #
Issue Date: Mar-2008
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:64 issue:11 pages:2605-2610
Abstract: A convenient microwave-assisted methodology is developed for the generation of 5-chloro-3-(dimethylamino)pyrazin-2(1H)-ones. The method entails a chemoselective desulfitative removal of a phenylthioether bond upon DMF/H2O treatment in the presence of sodium carbonate, yielding the desired compounds in 73-96%. (c) 2008 Elsevier Ltd. All rights reserved.
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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