Title: Transition metal-catalyzed orthogonal solid-phase decoration of the 2(1H)-pyrazinone scaffold using a sulfur linker
Authors: Kaval, Nadya ×
Singh, Brajendra Kumar
Ermolat'ev, Denis S
Claerhout, Stijn
Parmar, Virinder S
Van der Eycken, Johan
Van der Eycken, Erik #
Issue Date: May-2007
Publisher: Amer chemical soc
Series Title: Journal of combinatorial chemistry vol:9 issue:3 pages:446-453
Abstract: A new transition metal-catalyzed orthogonal solid-phase protocol for the synthesis of highly substituted 2(1H)-pyrazinones was developed, on the basis of Chan-Lam arylation and Liebeskind-Srogl cross-coupling reactions. This strategy opens the way for the generation of small libraries of 2(1H)-pyrazinone analogues for biological screening.
ISSN: 1520-4766
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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