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Title: Specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones for acetoxy drug: Protein transacetylase
Authors: Kumar, Ajit ×
Singh, Brajendra K
Sharma, Nawal K
Gyanda, Kapil
Jain, Sapan K
Tyagi, Yogesh K
Baghel, Anil S
Pandey, Mukesh
Sharma, Sunil K
Prasad, Ashok K
Jain, Subhash C
Rastogi, Ramesh C
Raj, Hanumantharao G
Watterson, Arthur C
Van der Eycken, Erik
Parmar, Virinder S #
Issue Date: Apr-2007
Publisher: Elsevier france-editions scientifiques medicales elsevier
Series Title: European journal of medicinal chemistry vol:42 issue:4 pages:447-455
Abstract: The earlier work carried out in our laboratory led to the identification of a novel rat liver microsomal enzyme termed as acetoxy drug: protein transacetylase (TAase), catalyzing the transfer of acetyl group from polyphenolic acetates (PA) to functional proteins. In this paper, we have reported the comparison of the specificities of acetoxy derivatives of coumarins, biscoumarins, chromones, flavones, isoflavones and xanthones with special reference to the phenyl moiety/bulky group on the pyran ring of PA. The results clearly indicated that compounds having phenyl moieties, when used as the substrates, resulted in a significant reduction of TAase catalyzed activity. The alteration in TAase catalyzed activation of NADPH cytochrome c reductase and inhibition of benzene-induced micronuclei in bone marrow cells by PA were in tune with their specificities to TAase. (c) 2006 Elsevier Masson SAS. All rights reserved.
URI: 
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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