Title: Calcium in the Golgi apparatus
Authors: Missiaen, Ludwig ×
Dode, Leonard
Vanoevelen, Jo
Raeymaekers, Luc
Wuytack, Frank #
Issue Date: May-2007
Publisher: Elsevier
Series Title: Cell Calcium vol:41 issue:5 pages:405-416
Abstract: The secretory-pathway Ca2+-ATPases (SPCAs) represent a recently recognized family of phosphorylation-type ATPases that supply the lumen of the Golgi apparatus with Ca2+ and Mn2+ needed for the normal functioning of this structure. Mutations of the human SPCA1 gene (ATP2C1) cause Hailey-Hailey disease, an amosomal dominant skin disorder in which keratinocytes in the suprabasal layer of the epidermis detach. We will first review the physiology of the SPCAs and then discuss how mutated SPCA1 proteins can lead to an epidermal disorder. (c) 2006 Elsevier Ltd. All rights reserved.
ISSN: 0143-4160
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Cellular and Molecular Medicine - miscellaneous
Laboratory of Molecular and Cellular Signaling
Physiology Section (-)
Laboratory of Cellular Transport Systems
× corresponding author
# (joint) last author

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