ITEM METADATA RECORD
Title: Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase
Authors: De Jonghe, Steven ×
Van Overmeire, I
Poulton, S
Hendrix, Christel
Busson, Roger
Van Calenbergh, Serge
De Keukeleire, Denis
Spiegel, S
Herdewijn, Piet #
Issue Date: 1999
Series Title: Bioorganic & medicinal chemistry letters vol:9 issue:21 pages:3175-3180
Abstract: Short-chain sphinganine analogues 8, 9, 18, and 19, as well as 3-fluoro-sphingosine analogues 25 and 26 were synthesized. Their potential as sphingosine kinase inhibitors was investigated, in combination with previously synthesized sphingosine and fluorinated sphinganine analogues.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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