Title: Synthesis of Highly Functionalized 2(1H)-Pyrazinone 3-Carboxamide Scaffolds
Authors: Pawar, Sonalika V
Pawar, Vijaykumar G
Dehaen, Wim
De Borggraeve, Wim # ×
Issue Date: Oct-2008
Publisher: Amer chemical soc
Series Title: Organic letters vol:10 issue:20 pages:4473-4476
Abstract: Synthesis of highly functionalized 2(1H)-pyrazinone 3-carboxamide derivatives is reported. A one-pot, two-step process including the base-mediated reaction of N,N-disubstituted aminoacetonitrile derivatives 18 with 3,5-dihalo-2(1H)-pyrazinones 1 afforded substituted aminoacetonitrile pyrazinone derivative 19, which on subsequent oxidation followed by transamidation of the resulting intermediate with primary or secondary amines gave the corresponding highly functionalized 2(1H)-pyrazinone 3-carboxamide derivatives 21.
ISSN: 1523-7060
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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