Title: Thrombin inhibits intercellular calcium wave propagation in corneal endothelial cells by modulation of hemichannels and gap junctions
Authors: D'hondt, Catheleyne ×
Ponsaerts, Raf
Srinivas, Sangly P
Vereecke, Johan
Himpens, Bernard #
Issue Date: Jan-2007
Publisher: Assoc research vision ophthalmology inc
Series Title: Investigative ophthalmology & visual science vol:48 issue:1 pages:120-133
Abstract: PURPOSE. Thrombin, a serine protease, breaks down the barrier integrity of corneal endothelial cells by phosphorylation of the regulatory light chain of myosin II (myosin light chain; MLC), which induces contractility of the actin cytoskeleton. This study was undertaken to investigate the effect of thrombin on gap junctional (GJIC) and paracrine (PIC) intercellular communication in cultured bovine corneal endothelial cells (BCECs).
ISSN: 0146-0404
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular and Cellular Signaling
Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

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