Title: Adenosine opposes thrombin-induced inhibition of intercellular calcium wave in corneal endothelial cells
Authors: D'hondt, Catheleyne ×
Srinivas, Sangly P
Vereecke, Johan
Himpens, Bernard #
Issue Date: Apr-2007
Publisher: Assoc research vision ophthalmology inc
Series Title: Investigative ophthalmology & visual science vol:48 issue:4 pages:1518-1527
Abstract: PURPOSE. In corneal endothelial cells, intercellular Ca2+ waves elicited by a mechanical stimulus involve paracrine intercellular communication, mediated by ATP release via connexin hemichannels, as well as gap junctional intercetlular communication. Both mechanisms are inhibited by thrombin, which activates RhoA and hence results in myosin light chain phosphorylation. This study was conducted to examine the effects of adenosine, which is known to oppose thrombin-induced RhoA activation, thereby leading to myosin light chain dephosphorylation, on gap junctional intercellular communication and paracrine intercellular communication in cultured bovine corneal endothelial cells.
ISSN: 0146-0404
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular and Cellular Signaling
Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

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