Title: Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
Authors: Vanheusden, Veerle ×
Munier-Lehmann, Hélène
Pochet, Sylvie
Herdewijn, Piet
Van Calenbergh, Serge #
Issue Date: Oct-2002
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:12 issue:19 pages:2695-2698
Abstract: A number of 2'- and 3'-modified thymidine 5'-O-monophosphate analogues were synthesized as potential leads for new anti-mycobacterial drugs. Evaluation of their affinity for Mycobacterium tuberculosis thymidine monophosphate kinase showed that a 2'-halogeno substituent and a 3'-azido function are the most favorable leads for further development of potent inhibitors of this enzyme.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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