Title: A potential prebiotic route to adenine from hypoxanthine
Authors: Lagoja, Irene
Herdewijn, Piet # ×
Issue Date: Jul-2005
Publisher: Verlag Helvetica Chimica Acta
Series Title: Chemistry & Biodiversity vol:2 issue:7 pages:923-927
Abstract: A possible reaction mechanism for the dehydration of glycinamide (3) and N,N'-diformylurea (4) yielding hypoxanthine (2) has been investigated. Furthermore, a potential prebiotic route converting hypoxanthine (2) into adenine (1) via phosphate activation followed by substitution reaction with NH3 was studied. This reaction mimics the proposed biochemical mechanism for the conversion of IMP to AMP.
ISSN: 1612-1872
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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