Title: An additional 2'-ribofuranose residue at a specific position of the DNA primer prevents its elongation by HIV-1 reverse transcriptase
Authors: Andreeva, OI ×
Golubeva, AS
Kochetkov, SN
Van Aerschot, Arthur
Herdewijn, Piet
Efimtseva, EV
Ermolinsky, BS
Mikhailov, SN #
Issue Date: Feb-2002
Series Title: Bioorganic & medicinal chemistry letters vol:12 issue:4 pages:681-684
Abstract: Oligodeoxynucleotides containing 2'-O-beta-D-ribofuranosyladenosine were prepared and used as modified primers in RNA-templated DNA synthesis catalyzed by HIV reverse transcriptase. It was shown that the additional 2'-ribofuranose residue in specific position of primer prevents its elongation.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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