Title: Synthesis and properties of phosphorylated 3'-O-beta-D-ribofuranosyl-2'-deoxythymidine
Authors: Efimtseva, EV ×
Shelkunova, AA
Mikhailov, SN
Nauwelaerts, Koen
Rozenski, Jef
Lescrinier, Eveline
Herdewijn, Piet #
Issue Date: 2003
Series Title: Nucleosides, nucleotides & nucleic acids vol:22 issue:4 pages:359-371
Abstract: A strategy was developed for the synthesis of 3'-O-beta-D-ribofuranosyl 2'-deoxythymidine derivatives using three different protecting groups, which allows the synthesis of a phosphoramidite building block for oligonucleotide synthesis. Likewise the 5'-O- and 5''-O-phosphorylated analogues were synthesized and their conformation was determined using NMR spectroscopy.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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