Title: Comparison of library screening techniques used in the development of dsDNA ligands
Authors: Chaltin, Patrick ×
Borgions, Filip
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: Jan-2003
Series Title: Bioorganic & medicinal chemistry letters vol:13 issue:1 pages:47-50
Abstract: The gel retardation and FID (fluorescent intercalator displacement) techniques have been compared for the selection of dsDNA binding ligands out of library mixtures. The selection procedure involves the synthesis and screening of unnatural oligopeptide libraries based on an iterative deconvolution procedure. Both methods yield comparable selection results and binding constants for the selected compounds, meaning that they can be considered as complementary in the discovery process of new antigene compounds. Furthermore, a quinazolin-2,4-dione amino acid has been identified as possessing interesting properties for interaction with dsDNA.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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