Title: Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase
Authors: Vanheusden, V ×
Van Rompaey, P
Munier-Lehmann, H
Pochet, Sylvie
Herdewijn, Piet
Van Calenbergh, S #
Issue Date: 2003
Series Title: Bioorganic & medicinal chemistry letters vol:13 issue:18 pages:3045-3048
Abstract: The affinity of a series of 2', 3'- and 5-modified thymidine analogues for Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) was evaluated. The affinities of several non-phosphorylated analogues are in the same order of magnitude as those of their phosphorylated congeners. In view of drug delivery problems associated with phosphorylated compounds, these 'free' nucleosides seem more promising leads in the search of TMPKmt inhibitors as novel anti-tuberculosis agents.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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