Title: Synthesis and biological evaluation of novel PDMP analogues
Authors: Hillaert, Ulrik ×
Boldin-Adamsky, Swetlana
Rozenski, Jef
Busson, Roger
Futerman, Anthony H
Van Calenbergh, Serge #
Issue Date: Aug-2006
Series Title: Bioorganic & medicinal chemistry vol:14 issue:15 pages:5273-84
Abstract: A new series of hybrid PDMP analogues, based both on PDMP and styryl analogues of natural ceramide, has been synthesized from D-serine. The synthetic route was developed such that future introduction of different aryl groups is straightforward. Biological evaluation, both in vitro on rat liver Golgi fractions as well as in HEK-293 and COS-7 cells, revealed two lead compounds with comparable inhibitory potency as PDMP, which could be elaborated to more potent inhibitors.
ISSN: 0968-0896
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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