Title: Isolation and structural elucidation of an impurity of cefradine
Authors: Zhu, Y
Hendrix, C
Busson, Roger
Janssen, Gerardus
Roets, Eugene
Hoogmartens, Jos # ×
Issue Date: Sep-1994
Series Title: Journal of pharmaceutical and biomedical analysis vol:12 issue:9 pages:1137-1140
Abstract: An impurity of unknown identity was isolated from commercial cefradine by liquid chromatography on poly (styrene-divinylbenzene) with HOAc (0.01 M)-CH3CN (94:6, v/v) as the mobile phase. The structure was elucidated as 4',5'-dihydrocefradine using nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS). The structure was confirmed by comparison with the chromatographic retention characteristics and photodiode-array detected ultraviolet spectrum of the synthetic compound and with its infrared, NMR and MS spectra. The presence of 4',5'-dihydrocefradine in cefradine has not been described previously.
ISSN: 0731-7085
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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