Title: Enzymatic resolution and base pairing properties of D- and L-cyclohexene nucleic acids (CeNA)
Authors: Gu, P ×
Schepers, Guy
Griebel, C
Rozenski, Jef
Gais, HJ
Herdewijn, Piet
Van Aerschot, Arthur #
Issue Date: 2005
Series Title: Nucleosides, nucleotides & nucleic acids vol:24 issue:5-7 pages:993-998
Abstract: An enzymatic transesterification reaction afforded large scale resolution of the cyclohexenol precursor needed for preparation of both series of CeNA building blocks. CeNA oligos of "D-like" chirality display a strong and selective interaction with RNA, while preserving RNase H activity, and therefore have potential as antisense constructs. CeNAs of opposite chirality form a self-pairing system on their own.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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