Title: Dissociable roles for the hippocampus and the amygdala in human cued versus context fear conditioning
Authors: Marschner, Andreas ×
Kalisch, Raffael
Vervliet, Bram
Vansteenwegen, Debora
Büchel, Christian #
Issue Date: 2008
Publisher: Soc neuroscience
Series Title: Journal of Neuroscience vol:28 issue:36 pages:9030-9036
Abstract: Lesion studies in animals have identified a critical role of the hippocampus in context fear conditioning. To extend these findings to human volunteers, we used functional magnetic resonance imaging to investigate neural responses associated with context fear conditioning in humans. Our novel conditioning paradigm consisted of aversive electrical shocks ( unconditioned stimulus) that were delivered either cue or context related. Differential evoked responses, related to the conditioned stimulus (CS), were found in the anterior cingulate cortex and the bilateral insular cortices, regions that have been implicated in anticipatory anxiety. In case of context conditioning, a similar pattern was observed during the presentation of the entire context. In line with previous conditioning studies, differential responses in the amygdala showed a time by stimulus interaction, suggesting rapid adaptation of CS-specific responses. More importantly, a similar differential decay of activation was observed during context conditioning in the hippocampus, in agreement with a role of the hippocampus in the acquisition phase of human context fear conditioning.
ISSN: 0270-6474
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Psychology of Learning and Experimental Psychopathology
× corresponding author
# (joint) last author

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