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Title: Characterisation and biodistribution of two neutral 99mTc(CO)3 complexes with a tridentate ligand
Authors: Rattat, Dirk ×
Cleynhens, Bernard
Bormans, Guy
Terwinghe, Christelle
Verbruggen, Alfons #
Issue Date: Oct-2005
Publisher: Pergamon Press
Series Title: Bioorganic & Medicinal Chemistry Letters vol:15 issue:19 pages:4192-4195
Abstract: N-(2-Mercapto-propyl)-1,2-phenylenediamine (MPPDA) and N-beta-aminoethylglycine (AEG) were labelled with 99mTc(CO)3(+) to form the neutral complexes [99mTc(CO)3(MPPDA)] and [99mTc(CO)3(AEG)]. Both complexes were formed in excellent yields and their identity was confirmed by LC-MS. In mice, none of the new tracer agents showed brain uptake. [(99m)Tc(CO)3(MPPDA)] was trapped mainly in the liver and excreted via the hepatobiliary system, whereas [99mTc(CO)3(AEG)] was excreted rapidly via the kidneys to the urine.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiopharmacy
× corresponding author
# (joint) last author

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