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Title: Cellular basis for triggered ventricular arrhythmias that occur in the setting of compensated hypertrophy and heart failure: considerations for diagnosis and treatment
Authors: Antoons, Gudrun ×
Oros, Avram
Bito, Virginie
Sipido, Karin
Vos, Marc A #
Issue Date: Nov-2007
Publisher: Research in Electrocardiology
Series Title: Journal of Electrocardiology vol:40 issue:6 pages:S8-S14
Conference: ISCE edition:32 location:Australia date:11-13 April 2007
25th IEEE International Conference on Consumer Electronics location:Las Vegas date:10-14 Jan 2007
Abstract: Malignant ventricular tachyarrhythmias are common among patients with hypertrophy and heart failure, and these arrhythimas can initiate by triggered activity. Abnormal repolarization and disturbed calcium handling due to remodeling processes are common features of the hypertrophied and failing heart that conspire to facilitate triggering events. These changes have a different cellular origin in compensated hypertrophy as compared with failure, which underscores the complexity of mechanisms that predispose the remodeled heart to arrhythmias. This hampers the identification of the vulnerable patient and adequate antiarrhythmic pharmacotherapy. Beat-to-beat variability of repolarization has been proposed as an early (noninvasive) electrographic detection method of triggered activity. An increase of variability heralds an enhanced risk of arrhythmias, and controlling this repolarization parameter by pharmacological agents is antiarrhythmic. Different drugs (flunarizine, ranolazine, K201, calmodulin kinase blockers) that are able to prevent and/or suppress triggered arrhythmias by specific mechanisms of action will be discussed. (c) 2007 Elsevier Inc. All rights reserved.
ISSN: 0022-0736
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiology
Experimental Cardiology
× corresponding author
# (joint) last author

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