Title: Structure of the alpha-homo-DNA:RNA duplex and the Function of Twist and Slide To Catalogue Nucleic Acid Duplexes
Authors: Nauwelaerts, Koen ×
Lescrinier, Eveline
Herdewijn, Piet #
Issue Date: 2007
Publisher: VCH Verlagsgesellschaft
Series Title: Chemistry - a European Journal vol:13 issue:1 pages:90-98
Abstract: High-resolution NMR studies of an alpha-homo-DNA:RNA duplex reveal the formation of a right-handed parallel-oriented helix. It differs significantly from a standard A- or B-type helix by a small twist value (26.2 degrees ), which leads to a helical pitch of 13.7 base pairs per helical turn, a negative inclination (-1.78 A) and a large x displacement (5.90 A). The rise (3.4 A) is similar to that found in B-DNA. The solution of this new helix structure has stimulated us to develop a mathematical and geometrical model based on slide and twist parameters to describe nucleic acid duplexes. All existing duplexes can be positioned within this landscape, which can be used to understand the helicalization process.
ISSN: 0947-6539
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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