Title: Synthesis and properties of aminopropyl nucleic acids.
Authors: Zhou, Ding
Lagoja, Irene
Rozenski, Jef
Busson, Roger
Van Aerschot, Arthur
Herdewijn, Piet # ×
Issue Date: Dec-2005
Publisher: Wiley-VCH
Series Title: Chembiochem vol:6 issue:12 pages:2298-2304
Abstract: Oligonucleotides that contain up to three aminopropyl nucleoside analogues have been synthesized. Dimers of aminopropyl adenine and thymidine were prepared and used as building blocks by applying phosphoramidite chemistry. Both R and S isomers of the aminopropyl nucleosides were used. This incorporation led to a reduction of thermal stability of double-stranded DNA. Furthermore, the (R)-adenine analogue, which yielded (S)-APNA, can be considered as a candidate for universal base pairing.
ISSN: 1439-4227
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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