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Title: Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides
Authors: Verheggen, I
Van Aerschot, Arthur
Van Meervelt, Luc
Rozenski, Jef
Wiebe, L
Snoeck, Robert
Andrei, Graciela
Balzarini, Jan
Claes, Paul
De Clercq, Erik
Herdewijn, Piet # ×
Issue Date: Mar-1995
Series Title: Journal of Medicinal Chemistry vol:38 issue:5 pages:826-835
Abstract: In view of the selective anti-HSV activity of 1,5-anhydro-2,3-dideoxy-2- (5-iodouracil-1-yl)-D-arabino-hexitol, a series of novel 1,5-anhydrohexitol nucleosides were synthesized and evaluated for their inhibitory activity against several viruses. The 5-iodouracil 3 and the 5-ethyluracil 4 derivatives are highly selective TK-dependent inhibitors of HSV-1 and HSV-2. Broad anti-herpes virus activity was noticed for 5-fluorocytosine 6 and 2,6-diaminopurine 10 analogues. From a transport study of 3, using the thymidine influx competition method, one can conclude that intracellular uptake of this compound most probably occurs by passive diffusion. X-ray analysis of compounds 3 and 9 showed that the heterocyclic base of 1,5-anhydrohexitol pyrimidine and purine is placed in the axial position and that the sugar ring adopts a slightly distorted chair conformation.
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Biochemistry, Molecular and Structural Biology Section
Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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