Title: Structural characterization and reactivity of gamma-octamolybdate functionalized by proline
Authors: Cartuyvels, Els
Van Hecke, Kristof
Van Meervelt, Luc
Gorller-Walrand, Christiane
Parac-Vogt, Tatjana # ×
Issue Date: Aug-2008
Publisher: Elsevier science inc
Series Title: Journal of inorganic biochemistry vol:102 issue:8 pages:1589-1598
Abstract: The reaction of molybdate and DL-proline at pH 3.4 results in the formation of a Na-4[Mo8O26(proO)(2)]center dot 22H(2)O Complex (pro = proline) in which two proline ligands are attached to molybdenum(VI) ions via monodentate coordination of the carboxylate groups. The structure of the complex was determined by single crystal X-ray diffraction and by combination of H-1, C-13 and Mo-95 NMR spectroscopy techniques in solution. The structure of the complex is strongly dependant on the pH. At native pH 3.4 the octamolybdate-type structure seems to be present in solution, but the increase of pH to 5.8 resulted in a rearrangement of the structure to a heptamolybdate-type structure. At physiological pH, the polyoxometalate framework was completely dissociated into the monomeric MoO42- unit. The reactivity of the Na-4[Mo8O26(proO)(2)]center dot 22H(2)O towards the hydrolysis of ATP was tested at different pH values. While in solution at pH 3.4 the hydrolysis proceeded to yield AMP (adenosine monophosphate) and ADP (adenosine diphosphate) in nearly equal amounts, reaction mixture at pH 5.8 gave ADP as the only product of hydrolysis after 24 h of reaction. At neutral pH, the hydrolysis of ATP was slower, but it proceeded to yield 75% of ADP after 48 h of reaction. (c) 2008 Elsevier Inc. All rights reserved.
ISSN: 0162-0134
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Biochemistry, Molecular and Structural Biology Section
× corresponding author
# (joint) last author

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