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Title: Evaluation of the formulation of solid dispersions by co-spray drying Itraconazole with Inutec SP1, a polymeric surfactant, in combination with PVPVA 64
Authors: Janssens, Sandrien ×
Van Humbeeck, Jan
Van den Mooter, Guy #
Issue Date: Oct-2008
Publisher: Wissenschaftliche Verlagsgesellschaft
Series Title: European Journal of Pharmaceutics and Biopharmaceutics vol:70 issue:2 pages:500-505
Abstract: In order to improve the in vitro performance and stability of co-spray-dried itraconazole/Inutec SP1 systems, the influence of adding PVPVA 64, a polymer that is compatible with itraconazole, was evaluated. Dissolution tests were carried out on several itraconazole/PVPVA 64/Inutec SP1 compositions and spraydried itraconazole/PVPVA 64 powders were used as references. The physicochemical properties of the samples were assessed with modulated temperature differential scanning calorimetry (MDSC), X-ray powder diffraction (XRD) and environmental scanning electron microscopy (ESEM). Physicochemical analysis revealed that there is no interaction between itraconazole and Inutec SP1 and that sufficient amount of PVPVA 64 is required to keep the drug molecularly dispersed. The improvement of the ternary solid dispersions over the binary solid dispersions was composition dependent. On one hand the increased drug/PVPVA 64 ratio in the ternary systems slowed dissolution down, on the other hand this was compensated by the solubilizing power of Inutec SP1.
ISSN: 0939-6411
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physical Metallurgy and Materials Engineering Section (-)
Drug Delivery and Disposition
× corresponding author
# (joint) last author

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