Title: Pharmacological comparison of two different insect models using the scorpion alpha-like toxin BmK M1 from Buthus martensii Karsch
Authors: Bosmans, Frank ×
Brône, Bert
Sun, Yan-Mei
Zhu, Rong-Huan
Xiong, Yu-Mei
Wang, Da-Cheng
Van Kerkhove, Emmy
Tytgat, Jan #
Issue Date: May-2005
Series Title: Protein and peptide letters vol:12 issue:4 pages:363-7
Abstract: In this study, the effect of the scorpion alpha-like toxin BmK M1 was investigated on isolated DUM neurons from Locusta migratoria and compared with the effect on para/tipE voltage-gated Na(+) channels (VGSC), cloned from Drosophila melanogaster. The two insects display different pharmacological properties regarding alpha-like toxins. Moreover, with the aid of the alpha-like toxin BmK M1 and 5 of its mutants, the importance of aromatic residues for the interaction of the toxin with the VGSC in L. migratoria and D. melanogaster, is shown.
ISSN: 0929-8665
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Toxicology and Pharmacology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science