Title: Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons
Authors: Van Overmeire, I ×
Boldin, S A
Dumont, F
Van Calenbergh, Serge
Slegers, G
De Keukeleire, Denis
Futerman, A H
Herdewijn, Piet #
Issue Date: 1999
Series Title: Journal of Medicinal Chemistry vol:42 issue:14 pages:2697-2705
Abstract: A series of D-erythro- and L-threo-ceramide analogues was synthesized and investigated for their ability to reverse the inhibitory effects of fumonisin B(1) (FB(1)) on axonal growth in hippocampal neurons. The analogues contained either a C(7) side chain or a phenyl group substituted for the C(13) residue present in naturally occurring ceramides, while the N-acyl chain length was reduced from C(16)-C(24) to C(2)-C(8). D-erythro-Ceramide 18a with a C(7) side chain and an N-acetyl residue and D-erythro-ceramide 20c with an aromatic side chain and an N-hexanoyl residue were most active in reversing the inhibitory effects of FB(1) on axonal growth, although the mechanism remains unclear.
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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