Title: Synthesis and stability of oligonucleotides containing acyclic achiral nucleoside analogues with two base moieties
Authors: Wu, Tongfei ×
Froeyen, Mathy
Schepers, Guy
Mullens, Kristof
Rozenski, Jef
Busson, Roger
Van Aerschot, Arthur
Herdewijn, Piet #
Issue Date: Jan-2004
Series Title: Organic letters vol:6 issue:1 pages:51-54
Abstract: [structure: see text] Nucleotide building blocks with two base moieties were synthesized and incorporated into oligonucleotides. One of the two bases is involved in base pairing within the double helix, while the other base is sticking out of the minor groove. This system may be used for presenting sequence information at the outside of the helix.
ISSN: 1523-7060
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
× corresponding author
# (joint) last author

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