Title: A monoclonal anti-PlGF antibody inhibits tumor growth and lymphatic metastasis without affecting healthy vessels
Authors: Fischer, Christian ×
Jonckx, Bart
Zacchigna, Serena
Mazzone, Max
Chorianopoulos, Emmanuel
Koch, Marta
Plaisance, Stephane
Ngo, Thu Hoa
De Mol, Maria
Dewerchin, Mieke
Autiero, Monica
Moons, Lieve
Stassen, Jean Marie
Collen, Desire
Carmeliet, Peter #
Issue Date: Apr-2007
Host Document: Gastroenterology vol:132 issue:4 pages:A70-A70
Conference: Digestive Disease Weeking Meeting/ASGE Postgraduate Course Meeting location:Washington, DC date:19-24 May 2007
Abstract: Novel antiangiogenic strategies with complementary mechanisms are needed to maximize efficacy and minimize resistance to current angiogenesis inhibitors. We explored the therapeutic potential and mechanisms of alpha PIGF, an antibody against placental growth factor (PIGF), a VEGF homolog, which regulates the angiogenic switch in disease, but not in health. alpha PIGF inhibited growth and metastasis of various tumors, including those resistant to VEGF(R) inhibitors (VEGF(R)Is), and enhanced the efficacy of chemotherapy and VEGF(R)Is. alpha PIGF inhibited angiogenesis, lymphangiogenesis, and tumor cell motility. Distinct from VEGF(R)Is, alpha PIGF prevented infiltration of angiogenic macrophages and severe tumor hypoxia, and thus, did not switch on the angiogenic rescue program responsible for resistance to VEGF(R)Is. Moreover, it did not cause or enhance VEGF(R)I-related side effects. The efficacy and safety of alpha PIGF, its pleiotropic and complementary mechanism to VEGF(R)Is, and the negligible induction of an angiogenic rescue program suggest that alpha PIGF may constitute a novel approach for cancer treatment.
ISSN: 0016-5085
Publication status: published
KU Leuven publication type: IMa
Appears in Collections:Vesalius Research Centre (-)
Molecular Genetics Section (-)
Molecular and Vascular Biology
Animal Physiology and Neurobiology Section - miscellaneous
Laboratory of Neurogenetics (-)
Laboratory of Tumor Inflammation and Angiogenesis (VIB-KU Leuven Centre for Cancer Biology) (+)
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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